Increased rates of invasive bacterial disease in late 2022.

Invasive bacterial disease is associated with significant morbidity and mortality. In winter 2022, there was an apparent increased rate of invasive bacterial disease compared to preceding years. Cross-site retrospective analysis of the three Children's Health Ireland (CHI) hospitals looking at children admitted between 1st October 2022-31st December 2022 (Q4) with community-acquired invasive bacterial disease, defined as an abscess in a normally sterile site in the head, neck and chest or isolation or PCR detection of Streptococcus pneumoniae, Neisseria meningitidis, Streptococcus pyogenes (Group A streptococcus) or Haemophilus influenzae from a normally sterile site. Case numbers were compared to Q4 in each of 2018-2021. Eighty-two children met the case definition in Q4 2022 vs 97 (Q4 2018-2021). In 2022, 42/82 (51%) were female, median age 3.75 years (1.5-8.25 years). Only 2 (2%) were immunosuppressed and 2 others (2%) had underlying neurodisability. Fifty (61%) were admitted on second or subsequent presentation to a healthcare setting. Fifty-six (68%) had an abscess in a sterile site. Bloodstream infection (positive blood culture or PCR: 24 (29%)) was the most common site of infection, followed by neck 22 (27%) and intracranial 12 (15%). Group A streptococcus (GAS) 27 (33%) was the most common organism isolated. Seven cases (9%) died in 2022 compared to 2 patients (2%) from 2018 to 2021 (p < 0.05). More children had Paediatric Overall Performance Category (POPC) scores > 1 in 2022 than 2018-2021 (p = 0.003).  Conclusion: Invasive bacterial diseases increased in Q4 2022 with higher morbidity and mortality than in the preceding 4 years. Group A streptococcal infection was the most significant organism in 2022. What is known: • Invasive bacterial disease is the leading cause of childhood mortality globally. • There was an increase in cases of invasive Group A streptococcus infections reported in many countries (including Ireland) during the winter of 2022/23. What is new: • Head, neck and chest abscesses increased in Q4 of 2022 compared to the previous 4 years combined. • Invasive bacterial infections in Q4 of 2022 were associated with higher rates of mortality (9%), paediatric intensive care unit (PICU) admission (24%) and requirement for surgical drainage or intervention (67%) than in the preceding years.

Identifying Risk Factors Associated with Fatal Drowning Accidents in the Paediatric Population: A Review of International Evidence.

INTRODUCTION: Evidence from Ireland's Childhood Mortality Register demonstrates that drowning is the second leading cause of death in children. It occurs more commonly in adolescent males engaged in summer water-based activities and in children aged 1-4 years with access to swimming pools/unprotected water sources. Despite being an island nation, a significant lack of guidelines exists to reduce drowning accidents in these at-risk populations. AIM: Review international evidence surrounding risk factors associated with drowning accidents in the paediatric population and existing risk-reduction guidelines.  Methods: Structured review of Cochrane, Cinahl, Pubmed Web of Science databases performed using search terms: ("risk factors" AND "drowning"), ("risk reduction" OR "prevention" OR "swim ability" AND "drowning"). Studies were included if satisfied age criteria (0-18 years). RESULTS: Evidence suggests that boys are at highest risk of drowning (1-4 yrs in swimming pools; adolescents in freshwater) with inadequate surveillance, inadequate availability of first responders, certain clinical diagnoses (developmental delay and seizure disorders), lack of swimming ability, and substance misuse in adolescents all posing an increased risk. Formal swimming education in those aged 4+ years, training of supervising adults in safe rescue, installation of isolation barriers, enforcing water safety guidelines, and regulations are all recommended by International Advisory Groups for prevention of drowning. CONCLUSION: In Ireland, drowning is the second leading cause of accidental paediatric death in the post-neonatal period, and an important cause of childhood fatalities globally. Risk factors increasing the likelihood of fatal paediatric drownings include gender and distinct age peaks. Certain modifiable risk factors relate to peri-event factors such as lack of supervision, to post-event responses, in particular including lack of trained personnel at the scene. There is a poverty of guidelines specifically targeting the paediatric populations; guidelines generally tend to be included into adult drowning reduction strategies. Specific targeting is required to protect those most at risk.